Daniel S. Tsze, MD

Pediatric Emergency Medicine
Pediatrics
Treats Children
Profile Headshot

Overview

Dr. Daniel Tsze is a board-certified pediatric emergency medicine physician and Professor of Pediatrics (in Emergency Medicine) at the Columbia University Irving Medical Center. He currently practices in the Pediatric Emergency Department at the NYP-Morgan Stanley Children’s Hospital.

Dr. Tsze conducts research that aims to improve and optimize the treatment of pain and distress and provision of procedural sedation for children in the emergency department. His specific areas of interest include intranasal analgesics and sedatives, the psychometric properties and clinical interpretation of self-report and observational measure of pain in children, integrative strategies for treating pain and distress, and the evaluation and treatment of headaches in children. He is currently the Principal Investigator of the PECARN HEADACHE study (Headache Assessment of Children for Emergent Intracranial Abnormalities), an NINDS R01 that aims to prospectively derive and internally validate a risk stratification model for identifying the risk of emergent intracranial abnormalities in children presenting with headaches to one of 18 emergency departments in PECARN. He is also a PI (MPI Tsze, Drendel) of the PECARN MoKA study (Morphine or Ketamine for Analgesia), an NIH HEAL Initiative U01 that aims to determine the effectiveness of intravenous sub-dissociative ketamine compared to intravenous morphine for treating children with acute pain who present to one of 8 emergency departments in PECARN. He is a member of the Society for Pediatric Sedation Research Committee.

Dr. Tsze received his MD from the University of British Columbia and his MPH from Brown University. He completed his Pediatric residency training at BC Children’s Hospital and his Pediatric Emergency Medicine fellowship at Hasbro Children’s Hospital.

Academic Appointments

  • Professor of Pediatrics (in Emergency Medicine) at CUMC

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center
  • NewYork-Presbyterian Morgan Stanley Children's Hospital
  • NewYork-Presbyterian Westchester

Languages

  • Mandarin

Gender

  • Male

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Credentials & Experience

Education & Training

  • University of British Columbia Faculty of Medicine (Canada)
  • Residency: British Columbia Children's Hospital
  • Fellowship: Hasbro Children's Hospital

Committees, Societies, Councils

Society for Pediatric Sedation: Research Committee, Immediate Past Chair

PECARN: Protocol Review and Development Subcommittee

Board Certifications

  • Pediatrics
  • Pediatric Emergency Medicine

Research

Dr. Tsze's research aims to improve and optimize the treatment of pain and provision of procedural sedation for children in the emergency department. His areas of interest include intranasal analgesics and sedatives, the psychometric properties and clinical interpretation of self-report and observational measures of pain in children, and integrative strategies for treating pain and distress.

Dr. Tsze is the PI for the HEADACHE study (Headache Assessment of Children for Emergent Intracranial Abnormalities). The HEADACHE study is an NINDS R01 that aims to derive and internally validate a risk stratification model for identifying the risk of emergent intracranial abnormalities in children presenting with headaches to one of 18 emergency departments in the Pediatric Emergency Care Applied Research Network (PECARN). He is also a PI (MPI Tsze, Drendel) of the MoKA study (Morphine or Ketamine for Analgesia). The MoKA study is an NIH HEAL Initiative U01 that aims to determine the effectiveness of intravenous sub-dissociative ketamine compared to intravenous morphine for treating children with acute pain who present to one of 8 emergency departments in PECARN.

Research Interests

  • Headache evaluation and treatment in the emergency department
  • Intranasal analgesics and sedatives
  • Pediatric pain management and procedural sedation in the emergency department
  • Self-report and observational measures of pain in children

Clinical Trials

  1. 1U01HD116253-01 Efficacy of Intravenous Sub-dissociative Ketamine versus Intravenous Morphine in Children with Acute Pain
  2. NCT04586504 Dose-Finding Study of Intranasal Midazolam for Procedural Sedation in Children
  3. NCT03755687 Effectiveness of Art Therapy Interventions for Treating Pain and Anxiety in Adolescents in the Emergency Department
  4. NCT02358681 Intranasal Ketorolac Versus Intravenous Ketorolac for Treatment of Migraine Headaches in Children
  5. NCT03054844 PREMIX vs PREMED Intranasal Lidocaine and Midazolam
  6. NCT03220880 Intranasal Dexmedetomidine Sedation in Children for Non-Painful Procedures
  7. NCT02437669 Intranasal Hydromorphone for the Treatment of Acute Pain in Children: A Pilot Study
  8. NCT01948908 Optimal Volume of Administration of Intranasal Midazolam in Children
  9. NCT01891812 Nitrous Oxide for Analgesia in Sickle Cell Vaso-occlusive Crisis
  10. NCT03004456 Distraction for Reduction of Pain Associated With Venipuncture in the Pediatric Post-Transplant Population
  11. NCT01549002 Efficacy of Intranasal Fentanyl for Reducing Pain during Abscess Incision and Drainage in Children